Where does the ampoule go in my skincare routine?

Use it after toner. If you use Missha First Treatment Essence, apply the ampoule after that instead. Spread or gently massage an appropriate amount over your skin, then pat lightly for absorption.

Which skin types is it recommended for?

Missha recommends it for normal, dry, oily, combination and sensitive skin.

What is the 77.2% Extreme Biome™ complex?

It is a proprietary blend formulated with 10 probiotic and fermented ingredients. The fermented ingredients are prepared with a three-step fermentation method.

Does the formula contain niacinamide?

Yes. Niacinamide appears in the ingredient declaration for the 70 ml ampoule.

Does the ingredient list include aromatic plant oils or limonene?

Yes. The declaration includes bergamot fruit, geranium flower, orange peel, lavender, chamomile flower and sandalwood oils, along with limonene.

Is 5X the same version as the earlier Night Repair Probio Ampoule?

The 5X ampoule is the renewed version of the earlier Probio Ampoule. Some retailers continue to use “Probio” in the 70 ml listing name.

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Missha

Time Revolution Night Repair Probio Ampoule 5X

What it is: A concentrated, leave-on facial ampoule that moisturizes overnight while supporting brighter, firmer-looking skin.

Overnight moisture
Brighter-looking radiance
Firmer, more elastic look
77.2% Extreme Biome™ complex

Net weight: 70 ml

Time Revolution Night Repair Probio Ampoule 5X

70ml ·$35.99 USD

Overnight moisture

Brighter-looking radiance

Firmer, more elastic look

77.2% Extreme Biome™ complex

Main active: Extreme Biome™ 10-Ferment Complex
Intensity: Standard

PRODUCT DETAILS

Good night, glow. This concentrated, leave-on ampoule is made for your evening routine. It helps moisturize skin while improving the look of brightness and radiance overnight. Its cosmetic benefits also include a firmer, more elastic appearance, giving you overnight moisture and visible radiance alongside firmer-looking skin in one step.

At the center is 77.2% Extreme Biome™, a proprietary blend formulated with 10 probiotic and fermented ingredients. The formula's ferments go through a three-step fermentation method. Niacinamide supports the brighter-looking story, while panthenol, sodium hyaluronate, Ceramide NP with cholesterol, and adenosine add familiar hydration, barrier-care and smoothing context.

The 5X ampoule is a fifth-generation overnight treatment and the renewed version of the earlier Night Repair Probio Ampoule. Some retailers still keep “Probio” in the listing name. Missha recommends it for all skin types, making its moisture, radiance and visible-firmness focus available across normal, dry, oily, combination and sensitive skin routines.

Learn more

GOES WELL WITH

100 Reedle Shot Stick Pouch$8.09 USD

1025 Dokdo Eye Cream$22.99 USD

1025 Dokdo Sleeping Pack$15.99 USD

1025 Dokdo Sun Cream$18.99 USD

1025 Dokdo Cream$24.99 USD

1025 Dokdo Pad$20.99 USD

1025 Dokdo Cleanser$11.99 USD

1025 Dokdo Lotion$14.99 USD

A night-focused ampoule for moisture, visible radiance, smoother-looking texture and a firmer, more elastic look.

Overnight moisture
Brighter-looking radiance
Firmness and elasticity
Smoother-looking texture

Key Ingredients

Abstract translucent blush-pink and pale sage sculptural folds on a warm ivory surface, softly lit with a gentle grounding shadow.

Extreme Biome™ 10-Ferment Complex

A 10-ferment complex that helps hydrate skin and supports a smoother, firmer, more refreshed appearance.

Niacinamide

Helps visibly brighten uneven tone and support the skin barrier.

Panthenol

Pro-vitamin B5 that helps skin hold moisture and feel softer and more comfortable.

Clear hydrogel spheres and droplets on a pale lilac background.

Hyaluronic Acid

Helps hydrate and visibly plump the skin.

Glossy peach-toned translucent sheets arranged in soft sculptural folds on a warm ivory surface with a gentle directional shadow.

Ceramide NP and Cholesterol

Complementary skin lipids that help support the moisture barrier and reduce moisture loss for softer, more comfortable skin.

Pleated lavender paper fan with a coral-red edge on a pale blush surface.

Adenosine

A skin-conditioning ingredient commonly used to help skin look smoother and soften the appearance of fine lines.

Dark amber rectangular bottle with a tall black cap and a vertical lavender label.

Concerns & Benefits

Your Concerns

1
Dehydration
For skin that feels short on moisture and could use overnight hydration.
2
Dullness
For when your complexion looks less radiant than you would like.
3

How To Use

1In your evening routine, apply the ampoule after toner or after Missha First Treatment Essence if you use it.
2Spread or gently massage an appropriate amount over your skin.
3Pat lightly to help it absorb.
4Leave the ampoule on; it is not rinsed off.

Small purple gradient dropper bottle centered on a pale green background.

Frequently asked questions

What is this overnight ampoule designed to do?

It is designed to moisturize overnight while improving the look of brightness, radiance, firmness and elasticity.

Keep learning

Customer reviews

Frequently Bought Together

Buy these products together

This itemTime Revolution Night Repair Probio Ampoule 5X$35.99 USD

100 Reedle Shot Stick Pouch$8.09 USD

1025 Dokdo Eye Cream$22.99 USD

Total price: $67.07 USD

This itemTime Revolution Night Repair Probio Ampoule 5X$35.99 USD

100 Reedle Shot Stick Pouch$8.09 USD

1025 Dokdo Eye Cream$22.99 USD

Total price: $67.07 USD

VT COSMETICS

100 Reedle Shot Stick Pouch

A travel-size evening booster for smoother-feeling, more refined-looking skin.

2 mL × 10$8.09 USD

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1025 Dokdo Eye Cream

Lightweight daily eye care for hydration, brightness and smoother-looking fine lines.

30 ml / 1.01 fl oz$22.99 USD

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1025 Dokdo Sleeping Pack

A lightweight, unscented overnight gel for hydration and smoother-feeling skin.

100 ml$15.99 USD

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1025 Dokdo Sun Cream

SPF 50+ PA++++ protection in a lightweight, no-white-cast lotion.

50 ml$18.99 USD

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1025 Dokdo Cream

A rich, unscented balm moisturizer for lasting hydration and a soft, cushioned feel.

80 ml$24.99 USD

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1025 Dokdo Pad

Two-sided toner care for tidier texture and balanced moisture.

70 pads / 120 g$20.99 USD

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1025 Dokdo Cleanser

Creamy, slightly acidic foam for a comfortable cleanse

150 ml$11.99 USD

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1025 Dokdo Lotion

A lightweight, unscented facial moisturizer with three forms of hyaluronic acid for lasting moisture without stickiness.

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Missha Time Revolution Night Repair Probio Ampoule 5X

Missha

Time Revolution Night Repair Probio Ampoule 5X

What it is: A concentrated, leave-on facial ampoule that moisturizes overnight while supporting brighter, firmer-looking skin.

Overnight moisture
Brighter-looking radiance
Firmer, more elastic look
77.2% Extreme Biome™ complex

Net weight: 70 ml

Time Revolution Night Repair Probio Ampoule 5X

70ml ·$35.99 USD

Overnight moisture

Brighter-looking radiance

Firmer, more elastic look

77.2% Extreme Biome™ complex

Main active: Extreme Biome™ 10-Ferment Complex
Intensity: Standard

PRODUCT DETAILS

Learn more

GOES WELL WITH

100 Reedle Shot Stick Pouch$8.09 USD

1025 Dokdo Eye Cream$22.99 USD

1025 Dokdo Sleeping Pack$15.99 USD

1025 Dokdo Sun Cream$18.99 USD

1025 Dokdo Cream$24.99 USD

1025 Dokdo Pad$20.99 USD

1025 Dokdo Cleanser$11.99 USD

1025 Dokdo Lotion$14.99 USD

A night-focused ampoule for moisture, visible radiance, smoother-looking texture and a firmer, more elastic look.

Overnight moisture
Brighter-looking radiance
Firmness and elasticity
Smoother-looking texture