How much should I use, and how do I finish applying it?

Use approximately two to three drops. Spread the ampoule gently over your face, then lightly tap until fully absorbed. It stays on your skin.

Can I apply it around my eyes?

Avoid the eye contour and direct contact with the eyes.

Does the brand recommend it for sensitive skin?

Yes. The brand says the ampoule is suitable for sensitive skin.

Is the formula fragrance-free?

Yes. The product is listed as formulated without fragrance.

Is this serum oil-free and non-comedogenic?

Yes. The brand describes it as oil-free and non-comedogenic.

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ma:nyo

Bifida Biome Complex Ampoule

What it is: A leave-on facial ampoule that provides lasting hydration, supports the moisture barrier and helps skin look plumper and smoother.

Lasting Hydration
Moisture-Barrier Support
Visibly Plumper Skin
Fragrance-Free Formula

Net weight: 50 ml / 1.6 fl oz

Bifida Biome Complex Ampoule

50ml ·$28.99 USD

Lasting Hydration

Moisture-Barrier Support

Visibly Plumper Skin

Fragrance-Free Formula

Main active: Bifida Biome™ Ferment Complex
Intensity: Supportive

PRODUCT DETAILS

Hello, hydration. This leave-on ampoule is a thoughtful choice when lasting moisture and barrier support are high on your list. It delivers lasting hydration and a visibly plumper look while helping nourish and fortify your skin's moisture barrier.

At its heart is the Bifida Biome complex, joined by five probiotic-derived ferments for a barrier-focused approach. The formula also contains 10 types of hyaluronic acid for ample hydration, giving thirsty skin a little more care without turning your routine into homework.

Reviewers commonly describe the texture as light yet viscous. Individual reviewers also mention quick absorption and a non-greasy, non-sticky feel, though experiences vary. The formula is listed as fragrance-free, silicone-free and oil-free, and the brand describes it as non-comedogenic and suitable for sensitive skin.

Alongside hydration and barrier care, the ampoule helps minimize the look of wrinkles for a smoother-looking finish. It can also be used on the neck, making it easy to extend the same care beyond your face.

Learn more

GOES WELL WITH

1025 Dokdo Cream$24.99 USD

1025 Dokdo Eye Cream$22.99 USD

1025 Dokdo Lotion$14.99 USD

100 Reedle Shot Stick Pouch$8.09 USD

1025 Dokdo Cleanser$11.99 USD

1025 Dokdo Pad$20.99 USD

1025 Dokdo Sleeping Pack$15.99 USD

1025 Dokdo Sun Cream$18.99 USD

A hydration-first ampoule that pairs moisture-barrier support with visibly plumper, smoother-looking skin.

Lasting hydration
Moisture-barrier support
Smoother-looking lines

Key Ingredients

Abstract translucent peach and blush sculptural folds with soft coral forms and suspended droplets, floating above a warm ivory surface with a diffused shadow.

Bifida Biome™ Ferment Complex

A bifida ferment complex that helps support the skin barrier and maintain a balanced, comfortable-looking complexion.

Translucent aqua, clear, and pale lilac gel forms with scattered droplets arranged on a clear circular surface against a softly lit ivory backdrop.

10-Form Hyaluronic Acid Complex

A blend of 10 hyaluronic-acid-related forms that helps support skin hydration.

Niacinamide

Helps visibly brighten uneven tone and support the skin barrier.

Squalane

Softens dry-feeling skin and adds slip to skin, body, hair and makeup.

Pleated lavender paper fan with a coral-red edge on a pale blush surface.

Adenosine

A skin-conditioning ingredient commonly used to help skin look smoother and soften the appearance of fine lines.

Real Results

95.2%Reported satisfaction with the overall feel after three weeks¹
100%Agreed skin affected by external irritants felt calmed after three weeks¹

Results published by MA:NYO. Individual results may vary.

1. MA:NYO product results

Close-up of translucent amber gel showing its glossy, fluid texture.

Concerns & Benefits

Your Concerns

1
Dehydration
For skin that feels short on moisture and could use lasting hydration.
2
Damaged Skin Barrier
For routines focused on nourishing and supporting the moisture barrier.

How To Use

1After toning, dispense approximately two to three drops onto your cheeks, avoiding the eye contour and direct contact with the eyes.
2Gently spread the ampoule evenly over your whole face. If desired, you can also apply it to your neck.
3Lightly tap with your fingers until fully absorbed. Leave it on as the next step in your skincare routine.

Glass dropper dispensing serum above an open hand beside the bottle.

Frequently asked questions

What are the main reasons to use this ampoule?

It provides lasting hydration, visibly plumps skin, supports the moisture barrier and helps minimize the look of wrinkles.

Keep learning

Customer reviews

Frequently Bought Together

Buy these products together

This itemBifida Biome Complex Ampoule$28.99 USD

1025 Dokdo Cream$24.99 USD

1025 Dokdo Eye Cream$22.99 USD

Total price: $76.97 USD

This itemBifida Biome Complex Ampoule$28.99 USD

1025 Dokdo Cream$24.99 USD

1025 Dokdo Eye Cream$22.99 USD

Total price: $76.97 USD

ROUND LAB

1025 Dokdo Cream

A rich, unscented balm moisturizer for lasting hydration and a soft, cushioned feel.

80 ml$24.99 USD

ROUND LAB

1025 Dokdo Eye Cream

Lightweight daily eye care for hydration, brightness and smoother-looking fine lines.

30 ml / 1.01 fl oz$22.99 USD

ROUND LAB

1025 Dokdo Lotion

A lightweight, unscented facial moisturizer with three forms of hyaluronic acid for lasting moisture without stickiness.

200 ml$14.99 USD

VT COSMETICS

100 Reedle Shot Stick Pouch

A travel-size evening booster for smoother-feeling, more refined-looking skin.

2 mL × 10$8.09 USD

ROUND LAB

1025 Dokdo Cleanser

Creamy, slightly acidic foam for a comfortable cleanse

150 ml$11.99 USD

ROUND LAB

1025 Dokdo Pad

Two-sided toner care for tidier texture and balanced moisture.

70 pads / 120 g$20.99 USD

ROUND LAB

1025 Dokdo Sleeping Pack

A lightweight, unscented overnight gel for hydration and smoother-feeling skin.

100 ml$15.99 USD

ROUND LAB

1025 Dokdo Sun Cream

SPF 50+ PA++++ protection in a lightweight, no-white-cast lotion.

50 ml$18.99 USD

MA:NYO Bifida Biome Complex Ampoule 50 ml | Sleepy Hello

ma:nyo

Bifida Biome Complex Ampoule

What it is: A leave-on facial ampoule that provides lasting hydration, supports the moisture barrier and helps skin look plumper and smoother.

Lasting Hydration
Moisture-Barrier Support
Visibly Plumper Skin
Fragrance-Free Formula

Net weight: 50 ml / 1.6 fl oz

Bifida Biome Complex Ampoule

50ml ·$28.99 USD

Lasting Hydration

Moisture-Barrier Support

Visibly Plumper Skin

Fragrance-Free Formula

Main active: Bifida Biome™ Ferment Complex
Intensity: Supportive

PRODUCT DETAILS

Learn more

GOES WELL WITH

1025 Dokdo Cream$24.99 USD

1025 Dokdo Eye Cream$22.99 USD

1025 Dokdo Lotion$14.99 USD

100 Reedle Shot Stick Pouch$8.09 USD

1025 Dokdo Cleanser$11.99 USD

1025 Dokdo Pad$20.99 USD

1025 Dokdo Sleeping Pack$15.99 USD

1025 Dokdo Sun Cream$18.99 USD

A hydration-first ampoule that pairs moisture-barrier support with visibly plumper, smoother-looking skin.

Lasting hydration
Moisture-barrier support
Smoother-looking lines