How do I apply the Spicule Retinol PDRN Cream?

Apply an appropriate amount evenly to clean skin after cleansing. Spread it along your skin’s texture, then lightly press with your palms and let it absorb.

Which visible skin concerns is this cream designed to address?

It is designed to care for the appearance of wrinkles, visible pores, uneven texture and loss of firmness, with added soothing and barrier-supporting care.

How much retinol, panthenol and spicule material does it contain?

The formula contains 1,000 ppm of Mary&May’s named Nano Liposome Retinol material, 2% panthenol and 2,000 ppm marine-derived microscopic spicules.

What ingredient represents PDRN in the published ingredient list?

The published ingredient list identifies Sodium DNA. It does not separately identify a Centella asiatica ingredient for the named CICA PDRN component.

Does the brand position this cream for sensitive skin?

Yes. Mary&May positions its panthenol, Ceramide NP, hyaluronic acid and allantoin combination as gentle enough for sensitive skin. The brand also states that a skin-irritation test was completed, without publishing the protocol or measurements.

Is the cream fragrance-free?

Yes. iHerb lists the exact 15 g cream as fragrance-free.

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Mary&May

Spicule Retinol PDRN Cream

What it is: A 15 g facial cream combining microscopic spicules, retinol and PDRN-related Sodium DNA to care for visible pores, fine lines, uneven texture and firmness.

Smoother-looking texture
Visible pore care
Softer-looking fine lines
Moisture and barrier support

Net weight: 15 g

Spicule Retinol PDRN Cream

15g ·$9.99 USD

Smoother-looking texture

Visible pore care

Softer-looking fine lines

Moisture and barrier support

Main active: Hydrolyzed Sponge Spicules
Intensity: Advanced

PRODUCT DETAILS

Meet a focused facial cream for the appearance of visible pores, fine lines, uneven texture and firmness. The compact 15 g formula brings spicules and retinol together with moisture-supporting ingredients for a balanced approach to visible skin concerns.

At its heart are 2,000 ppm marine-derived microscopic spicules, which support more intensive delivery and texture care. Retinol complements this focused approach and may help soften the look of fine lines and uneven texture with consistent, carefully introduced leave-on use.

The formula balances its targeted ingredients with 2% panthenol, Ceramide NP, sodium hyaluronate and allantoin. These ingredients bring moisture, barrier support and soothing care, helping make the cream a thoughtful fit when dryness accompanies your texture concerns.

It is also fragrance-free and designed with sensitive skin in mind. You get focused care for texture, pores and fine lines, with supportive moisture ingredients woven into the same cream step.

Learn more

GOES WELL WITH

100 Collagen Reedle Shot Stick Pouch$9.49 USD

100 PRO CICA Reedle Shot Stick Pouches$9.49 USD

100 Reedle Shot Stick Pouch$8.09 USD

1025 Dokdo Sleeping Pack$15.99 USD

100 RETI-A Reedle Shot$9.49 USD

1+1 Toning C Vita Shot Ampoule$28.99 USD

1% Oligo Hyaluronic Acid Toner$15.99 USD

1025 Dokdo Eye Cream$22.99 USD

Focused appearance care meets moisture and barrier support in one compact facial cream.

Smoother-looking texture
Pore appearance care
Softens the look of lines
Barrier-minded moisture

Key Ingredients

A cluster of translucent, pale peach pointed sculptural forms with small droplets, arranged on a warm ivory surface under soft directional light.

Hydrolyzed Sponge Spicules

Microscopic sponge-derived spicules that create a noticeable, stimulating feel in cosmetic formulas.

Three open mauve, apricot and auburn grooves arc across one warm-ivory matte plaster surface beside a tiny coral point.

Retinol

May help soften the look of fine lines and uneven texture with consistent, carefully introduced leave-on use.

Panthenol

Pro-vitamin B5 that helps skin hold moisture and feel softer and more comfortable.

Niacinamide

Helps visibly brighten uneven tone and support the skin barrier.

Overlapping ivory wax-like layers on a warm blush background, representing ceramide barrier lipids.

Ceramides

Barrier-supporting lipids that help reduce moisture loss and ease visible dryness.

Clear hydrogel spheres and droplets on a pale lilac background.

Hyaluronic Acid

Helps hydrate and visibly plump the skin.

Seven rose and lilac glass lozenges form a loose sequence across a blush pedestal against a muted plum backdrop.

PDRN

A DNA-fragment skin conditioner commonly used to help skin look smoother, plumper and more resilient.

Three oversized translucent, softly faceted glass crystals arranged on a pale lavender stage above a blush background with a small coral accent.

Allantoin

Helps soothe and soften dry, rough-feeling skin.

Several silver tubes and white-and-yellow cartons arranged on gray blocks with yellow cream dots.

Concerns & Benefits

Your Concerns

1
Uneven Texture
When your skin's surface looks uneven and you want a more refined appearance.
2
Visible Pores
When visible pores are drawing more attention than you would like.

How To Use

1After cleansing, take an appropriate amount and spread it evenly over clean skin, following your skin’s texture.
2Lightly press your face with your palms and let the cream absorb.

Single upright silver tube on a yellow background with a yellow cream drop near the upper tube.

Frequently asked questions

Is this a face cream or a serum?

It is a facial cream supplied in a 15 g tube.

Keep learning

Customer reviews

Frequently Bought Together

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This itemSpicule Retinol PDRN Cream$9.99 USD

100 Collagen Reedle Shot Stick Pouch$9.49 USD

100 PRO CICA Reedle Shot Stick Pouches$9.49 USD

Total price: $28.97 USD

This itemSpicule Retinol PDRN Cream$9.99 USD

100 Collagen Reedle Shot Stick Pouch$9.49 USD

100 PRO CICA Reedle Shot Stick Pouches$9.49 USD

Total price: $28.97 USD

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100 Collagen Reedle Shot Stick Pouch

Beginner-friendly texture care with moisture, firmness and a refreshing, non-sticky finish.

2 ml × 10 sachets$9.49 USD

VT COSMETICS

100 PRO CICA Reedle Shot Stick Pouches

Daily texture care with soothing hydration, one travel-friendly pouch at a time.

2 ml × 10 pouches$9.49 USD

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100 Reedle Shot Stick Pouch

A travel-size evening booster for smoother-feeling, more refined-looking skin.

2 mL × 10$8.09 USD

ROUND LAB

1025 Dokdo Sleeping Pack

A lightweight, unscented overnight gel for hydration and smoother-feeling skin.

100 ml$15.99 USD

VT COSMETICS

100 RETI-A Reedle Shot

A beginner-friendly evening serum for smoother-looking texture, refined-looking pores and radiant skin.

2 ml × 10 sachets$9.49 USD

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1+1 Toning C Vita Shot Ampoule

15% vitamin C and sponge micro-spicules for brighter, smoother, hydrated-looking skin.

20g + 20g$28.99 USD

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1% Oligo Hyaluronic Acid Toner

Lightweight hydration with 1% hydrolyzed sodium hyaluronate.

150 ml$15.99 USD

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1025 Dokdo Eye Cream

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30 ml / 1.01 fl oz$22.99 USD

Mary&May Spicule Retinol PDRN Face Cream 15g | Sleepy Hello

Mary&May

Spicule Retinol PDRN Cream

What it is: A 15 g facial cream combining microscopic spicules, retinol and PDRN-related Sodium DNA to care for visible pores, fine lines, uneven texture and firmness.

Smoother-looking texture
Visible pore care
Softer-looking fine lines
Moisture and barrier support

Net weight: 15 g

Spicule Retinol PDRN Cream

15g ·$9.99 USD

Smoother-looking texture

Visible pore care

Softer-looking fine lines

Moisture and barrier support

Main active: Hydrolyzed Sponge Spicules
Intensity: Advanced

PRODUCT DETAILS

It is also fragrance-free and designed with sensitive skin in mind. You get focused care for texture, pores and fine lines, with supportive moisture ingredients woven into the same cream step.

Learn more

GOES WELL WITH

100 Collagen Reedle Shot Stick Pouch$9.49 USD

100 PRO CICA Reedle Shot Stick Pouches$9.49 USD

100 Reedle Shot Stick Pouch$8.09 USD

1025 Dokdo Sleeping Pack$15.99 USD

100 RETI-A Reedle Shot$9.49 USD

1+1 Toning C Vita Shot Ampoule$28.99 USD

1% Oligo Hyaluronic Acid Toner$15.99 USD

1025 Dokdo Eye Cream$22.99 USD

Focused appearance care meets moisture and barrier support in one compact facial cream.

Smoother-looking texture
Pore appearance care
Softens the look of lines
Barrier-minded moisture