Is the PDRN in this cream from salmon?

Yes. Medicube states the PDRN here is salmon DNA — polydeoxyribonucleotide extracted from salmon, and it appears on the ingredient list as Sodium DNA. Two things follow from that. Anyone avoiding fish-derived cosmetics will want to know before buying, and it is the reason this product does not carry our vegan tag, however plant-sounding the rest of the pink peptide story reads.

Can I use it every day?

Medicube says yes — it is designed for daily eye care. The one caveat is the retinol: Medicube suggests building up slowly when your skin has not met retinol before, or when it tends to run sensitive, and letting the way it responds set the pace. Starting at a few nights a week and adding more once it settles is the calmer route in.

Can I use it alongside my other retinol products?

Carefully. Because this eye cream already contains retinol, Medicube advises caution when a second retinol or another strong active lands on the same patch of skin. In practice that usually means keeping your face retinol clear of the orbital bone on the nights you use this one, or alternating the two across the week, rather than stacking both in a single session.

Will it help with dark circles?

It works on how they look rather than on what causes them. Medicube says salmon DNA PDRN and niacinamide help improve the appearance of uneven tone and dull-looking skin around the eyes, supporting a clearer and more radiant-looking eye area. Shadowing that comes from bone structure, hollowing, or the vessels beneath thin skin sits outside what any cream can change, so it is worth setting expectations there.

What is the texture like, and where does it sit in a routine?

Silky and light. It absorbs quickly without feeling heavy or sticky, so it does not leave a film behind. The flat white nozzle dispenses a small dose that you pat in with a fingertip, keeping clear of the eye itself. Medicube places it at the very end of a routine, and its PDRN hydrogel eye patches can go on top once this layer has sunk in.

How soon might I notice anything?

Medicube measured its own figures after one week of use, and both are shown in Real Results above. Eye products generally reward patience more than enthusiasm, so give it a few consistent weeks before deciding. Because retinol is in the formula, going slowly and steadily tends to be more useful than using more of it, and an easier start usually means fewer weeks spent adjusting.

Can I use it while pregnant or breastfeeding?

This formula contains retinol, and guidance on topical retinoids during pregnancy and breastfeeding varies. That is not a call we are able to make on your behalf, so please check with your doctor or midwife before adding any retinol product to your routine. If you would rather not have the conversation right now, it is entirely reasonable to set this one aside until later.

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MEDICUBE

PDRN Pink Peptide Eye Cream 30ml

Hydrating
Brightens
Smooths
Lightweight

PDRN Pink Peptide Eye Cream 30ml

30ml ·$20.99 USD

Hydrating

Brightens

Smooths

Lightweight

PRODUCT DETAILS

PDRN Pink Peptide Eye Cream is Medicube's leave-on cream for the thin skin around the eyes. A flat applicator tip releases a small dose of pale pink cream that melts in with a silky, lightweight feel and absorbs quickly without turning heavy or tacky. It goes on as the final step of a routine, patted gently along the bone under each eye.

The formula leads on PDRN — polydeoxyribonucleotide, sourced from salmon and listed as Sodium DNA — supported by niacinamide printed at 5% on the tube and retinol Medicube describes as 99% pure. Peptides, caffeine, adenosine and three forms of hyaluronic acid fill out the rest, and no added fragrance appears anywhere on the ingredient list.

It fits anyone who wants one eye product covering several complaints at once — tone, texture, fine lines and comfort — instead of a plain hydrator. Medicube lists it as suitable for combination, dry, oily and sensitive skin, and asks anyone new to retinol to build up slowly rather than starting nightly.

Medicube's own one-week study is summarised in Real Results below. The tube holds 30 ml, and the brand designs it to layer with the rest of its PDRN range, including the hydrogel eye patches.

Learn more

GOES WELL WITH

ANUA Niacinamide 5 + TXA Brightening Pad 210ml (60 pads)$19.99 USD

100 Reedle Shot Stick Pouch$8.09 USD

100 VITA-LIGHT Reedle Shot$9.49 USD

1025 Dokdo Cleanser$11.99 USD

1025 Dokdo Lotion$14.99 USD

1025 Dokdo Sleeping Pack$15.99 USD

1025 Dokdo Cream$24.99 USD

100 Collagen Reedle Shot Stick Pouch$9.49 USD

One eye cream doing several jobs at once: the look of firmness, an evener tone, and hydration that stays comfortable all day.

Firmer-looking under-eyes
Brighter, more even tone
Softer-looking fine lines
Hydration where skin is thinnest
Silky, non-sticky finish

Key Ingredients

Seven rose and lilac glass lozenges form a loose sequence across a blush pedestal against a muted plum backdrop.

PDRN

A DNA-fragment skin conditioner commonly used to help skin look smoother, plumper and more resilient.

Niacinamide

Helps visibly brighten uneven tone and support the skin barrier.

Three open mauve, apricot and auburn grooves arc across one warm-ivory matte plaster surface beside a tiny coral point.

Retinol

May help soften the look of fine lines and uneven texture with consistent, carefully introduced leave-on use.

Real Results

22.5%More moisture around the eye area after one week¹
2.9%Firmer-looking skin around the eye area after one week¹

Based on Medicube's one-week clinical trial. Individual results may vary.

1. Medicube one-week clinical trial

Pale pink cream swept into one thick, glossy curve — dense rather than watery, and tinted rather than white.

Concerns & Benefits

Your Concerns

1
Dark Circles
The shadow under your eyes that concealer sits in rather than covers by mid-morning.
2
Fine Lines And Wrinkles
Fine creases at the outer corner that stay visible once your face has relaxed.

How To Use

1As the last step of your skincare routine, dispense a small amount from the flat nozzle and apply it to the eye area.
2Pat lightly with a fingertip until it absorbs, avoiding direct contact with the eyes themselves.
3Designed for daily use. Because the formula contains retinol, Medicube recommends easing in gradually if retinol is new to you or your skin runs sensitive, then adjusting how often you use it. Take care around the eye area if you also apply another retinol or a strong active there.
4Medicube suggests following with its PDRN hydrogel eye patches once this has absorbed, and pairing it with the rest of the PDRN line.

A bead of cream released from the flat nozzle, roughly the small dose a single under-eye application takes.

Frequently asked questions

What does this eye cream actually do?

It works on three things around the eyes at the same time: the look of firmness, the evenness of tone, and hydration. Medicube positions it for fine lines, loss of elasticity and uneven-looking under-eye skin, with salmon DNA PDRN, niacinamide, retinol and peptides carrying that. If you would rather buy one product covering several under-eye complaints than a plain hydrating step, this is the shape of thing you are looking for.

Keep learning

Customer reviews

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This itemPDRN Pink Peptide Eye Cream 30ml$20.99 USD

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100 Reedle Shot Stick Pouch$8.09 USD

Total price: $49.07 USD

This itemPDRN Pink Peptide Eye Cream 30ml$20.99 USD

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A jelly-like evening ampoule for brighter, more even-looking skin in single-use pouches.

2 ml × 10 pouches$9.49 USD

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Creamy, slightly acidic foam for a comfortable cleanse

150 ml$11.99 USD

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A lightweight, unscented facial moisturizer with three forms of hyaluronic acid for lasting moisture without stickiness.

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A lightweight, unscented overnight gel for hydration and smoother-feeling skin.

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Medicube PDRN Pink Peptide Eye Cream 30ml | Sleepy Hello

MEDICUBE

PDRN Pink Peptide Eye Cream 30ml

Hydrating
Brightens
Smooths
Lightweight

PDRN Pink Peptide Eye Cream 30ml

30ml ·$20.99 USD

Hydrating

Brightens

Smooths

Lightweight

PRODUCT DETAILS

Medicube's own one-week study is summarised in Real Results below. The tube holds 30 ml, and the brand designs it to layer with the rest of its PDRN range, including the hydrogel eye patches.

Learn more

GOES WELL WITH

ANUA Niacinamide 5 + TXA Brightening Pad 210ml (60 pads)$19.99 USD

100 Reedle Shot Stick Pouch$8.09 USD

100 VITA-LIGHT Reedle Shot$9.49 USD

1025 Dokdo Cleanser$11.99 USD

1025 Dokdo Lotion$14.99 USD

1025 Dokdo Sleeping Pack$15.99 USD

1025 Dokdo Cream$24.99 USD

100 Collagen Reedle Shot Stick Pouch$9.49 USD

One eye cream doing several jobs at once: the look of firmness, an evener tone, and hydration that stays comfortable all day.

Firmer-looking under-eyes
Brighter, more even tone
Softer-looking fine lines
Hydration where skin is thinnest
Silky, non-sticky finish

Key Ingredients