Where does it go in my routine, and how should I apply it?

Use it as the first skincare step on bare facial skin. Apply an appropriate amount, avoid the eye and lip areas, and rub it in to aid absorption. Once absorbed, finish with a hydrating formula.

Should I rinse the ampoule off after it absorbs?

No. Leave it on, then continue with a hydrating formula after it absorbs.

Does the 25000 ampoule tingle when applied?

Yes. The range is described as tingling, and the 25000 ampoule is flagged as meaningfully stimulating. The sensation may persist for some time.

What is the texture and after-feel like?

It is described as lightweight, quick-absorbing and non-sticky, with a tingling sensation that may linger.

Which skin types is it for, and what should sensitive skin know?

It is designated for all skin types. If you have allergic, troubled or sensitive skin, patch-test a localized area before use; this is a stimulating formula.

Which exosome-derived ingredients are declared, and in what amounts?

The formula declares Lactobacillus Extracellular Vesicles at 154 ppm and Milk Exosomes at 10 ppm. The “25000” variant name is not the concentration of either ingredient.

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MEDICUBE

Zero One Day Exosome Shot Pore Ampoule 25000

What it is: A leave-on micro-spicule face ampoule for intensive care of visible pores and uneven-looking texture.

Visible pore refinement
Smoother-looking texture
Lightweight, non-sticky feel
Weekly evening care

Net weight: 13 ml

Zero One Day Exosome Shot Pore Ampoule 25000

13ml ·$22.99 USD

Visible pore refinement

Smoother-looking texture

Lightweight, non-sticky feel

Weekly evening care

Main active: Lactobacillus Extracellular Vesicles and Milk Exosomes
Intensity: Advanced

PRODUCT DETAILS

Meet a leave-on face ampoule made for intensive pore-focused care and smoother-looking uneven texture. The 25000 option is the range’s INTENSE variant, designed for a seven-day care cycle rather than everyday use.

Its hydrolyzed sponge spicules give the formula a delivery-focused, stimulating character. A tingling sensation may linger for a while—helpful to know before this little shot joins your shelf.

For the look of your skin, the ampoule is designed to refine visible pores and smooth uneven-looking texture. Niacinamide supports more even-looking tone and oil control, while gluconolactone and betaine salicylate offer gentle exfoliating support for a smoother finish.

The texture is lightweight, quick-absorbing and non-sticky. Panthenol and Ceramide NP add soothing and barrier-supporting care, giving this focused formula a considerate supporting cast.

Learn more

GOES WELL WITH

2X Fresh Bam Balm To Foam$24.99 USD

30 Seconds Quick Bubble Mask LIFT$28.99 USD

100 Reedle Shot Stick Pouch$8.09 USD

300 Reedle Shot Stick Pouch$9.19 USD

5α Control Clearing Cream$31.99 USD

AC BHA Foam Cleansing$16.99 USD

1025 Dokdo Cleanser$11.99 USD

1025 Dokdo Eye Cream$22.99 USD

Explore focused pore and texture care, with added support for tone, excess oil and the skin barrier.

Refines the look of visible pores
Smooths uneven-looking texture
Helps reduce excess sebum
Boosts the look of radiance

Key Ingredients

Lactobacillus Extracellular Vesicles and Milk Exosomes

A paired exosome complex used to support visible pore care and a glass-glow appearance.

A cluster of translucent, pale peach pointed sculptural forms with small droplets, arranged on a warm ivory surface under soft directional light.

Hydrolyzed Sponge Spicules

Microscopic sponge-derived spicules that create a noticeable, stimulating feel in cosmetic formulas.

Niacinamide

Helps visibly brighten uneven tone and support the skin barrier.

A translucent ivory abstract folded form with clear droplets rests on a softly lit peach surface, casting a gentle shadow.

Betaine Salicylate

A gentle BHA exfoliant that helps lift away dead skin and pore-clogging sebum for a smoother, more refined-looking texture.

Gluconolactone

A gentle exfoliating PHA that helps smooth skin texture while attracting moisture.

Panthenol

Pro-vitamin B5 that helps skin hold moisture and feel softer and more comfortable.

Overlapping ivory wax-like layers on a warm blush background, representing ceramide barrier lipids.

Ceramides

Barrier-supporting lipids that help reduce moisture loss and ease visible dryness.

A blush paper ribbon curves across an ivory platform with a pale lavender panel behind.

Peptides

Some exact peptide forms may support smoother, firmer-looking skin; evidence varies by peptide and formula.

Real Results

66%Reduction in excess sebum after four weeks¹
54%Improvement in skin radiance after one use¹
10.4%Improvement in skin smoothness after four weeks¹
5.4%Improvement in skin texture after four weeks¹

Results published on shopee.com.br. Individual results may vary.

1. shopee.com.br product results

Woman's face with dotted circles marking the nose, cheeks and chin.

Concerns & Benefits

Your Concerns

1
Visible Pores
For pores that look more noticeable than you’d like.
2
Uneven Texture
For skin that looks less smooth or even.
3

How To Use

1Every seven days, use in the evening after cleansing as the first step in your skincare routine.
2Apply an appropriate amount to bare facial skin, avoiding the eye and lip areas, then rub it in to aid absorption.
3Leave the ampoule on; do not rinse it off.
4Once it has absorbed, finish with a hydrating formula.

Angled close-up of the pump dispensing a white droplet beside the clear cap.

Frequently asked questions

Is the 25000 ampoule meant for daily or weekly use?

Weekly, not daily. Use it every seven days in the evening after cleansing.

Keep learning

Customer reviews

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This itemZero One Day Exosome Shot Pore Ampoule 25000$22.99 USD

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Total price: $76.97 USD

This itemZero One Day Exosome Shot Pore Ampoule 25000$22.99 USD

2X Fresh Bam Balm To Foam$24.99 USD

30 Seconds Quick Bubble Mask LIFT$28.99 USD

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MEDICUBE Zero One Day Exosome Shot 25000 Ampoule

MEDICUBE

Zero One Day Exosome Shot Pore Ampoule 25000

What it is: A leave-on micro-spicule face ampoule for intensive care of visible pores and uneven-looking texture.

Visible pore refinement
Smoother-looking texture
Lightweight, non-sticky feel
Weekly evening care

Net weight: 13 ml

Zero One Day Exosome Shot Pore Ampoule 25000

13ml ·$22.99 USD

Visible pore refinement

Smoother-looking texture

Lightweight, non-sticky feel

Weekly evening care

Main active: Lactobacillus Extracellular Vesicles and Milk Exosomes
Intensity: Advanced

PRODUCT DETAILS

Its hydrolyzed sponge spicules give the formula a delivery-focused, stimulating character. A tingling sensation may linger for a while—helpful to know before this little shot joins your shelf.

The texture is lightweight, quick-absorbing and non-sticky. Panthenol and Ceramide NP add soothing and barrier-supporting care, giving this focused formula a considerate supporting cast.

Learn more

GOES WELL WITH

2X Fresh Bam Balm To Foam$24.99 USD

30 Seconds Quick Bubble Mask LIFT$28.99 USD

100 Reedle Shot Stick Pouch$8.09 USD

300 Reedle Shot Stick Pouch$9.19 USD

5α Control Clearing Cream$31.99 USD

AC BHA Foam Cleansing$16.99 USD

1025 Dokdo Cleanser$11.99 USD

1025 Dokdo Eye Cream$22.99 USD

Explore focused pore and texture care, with added support for tone, excess oil and the skin barrier.

Refines the look of visible pores
Smooths uneven-looking texture
Helps reduce excess sebum
Boosts the look of radiance

Key Ingredients