Can it be used in both the morning and evening?

Yes. The directions support using the cream in both your morning and evening routines.

What kind of texture and finish does it have?

It has a rich, replenishing cream texture and leaves a smooth, radiant-looking finish.

Which featured ingredients support the moisture-barrier claim?

Ceramide NP, squalane, hyaluronic acid and panthenol make up the featured blend that helps support the skin's moisture barrier.

How much Sodium DNA, the PDRN-associated ingredient, is listed?

Sodium DNA, the ingredient associated with the cream's PDRN positioning, is listed at 1 ppm.

Does the formula contain rose-derived ingredients?

Yes. The ingredient declaration includes rose flower oil, Rosa Damascena flower water, Rosa Damascena flower oil and rose extract.

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Mediheal

PDRN Derma Cream

Q: Which skin types is this cream intended for?

It is intended for all skin types, including sensitive skin.

What it is: A rich leave-on face cream that moisturizes while supporting a smooth, radiant-looking finish and the appearance of pores.

Moisture-barrier support
Rich, replenishing hydration
Smoother-looking pores
Radiant-looking finish

Net weight: 50 ml

PDRN Derma Cream

50ml ·$22.99 USD

Moisture-barrier support

Rich, replenishing hydration

Smoother-looking pores

Radiant-looking finish

Main active: PDRN
Intensity: Supportive

PRODUCT DETAILS

Hello, replenishment. This leave-on face cream brings rich, replenishing moisture and a smooth, radiant-looking finish to skin that feels short on hydration.

Ceramide NP, squalane, hyaluronic acid and panthenol form a supportive blend that helps support the moisture barrier. Together, they give this cream a clear place in a routine focused on moisture and barrier care.

The PDRN complex adds a pore-focused benefit, helping to temporarily minimize the appearance of pore area, depth and count after four weeks. Niacinamide and adenosine complement it by helping to enhance the look of firmness and glow.

It's intended for all skin types, including sensitive skin. It may be an especially helpful fit when dehydration, dullness, enlarged-looking pores or reduced elasticity are among your concerns. The result is a rich final layer with a polished glow—care that feels considered, without making your routine feel complicated.

Learn more

GOES WELL WITH

100 RETI-A Reedle Shot$9.49 USD

100 Reedle Shot Stick Pouch$8.09 USD

100 VITA-LIGHT Reedle Shot$9.49 USD

1025 Dokdo Eye Cream$22.99 USD

1025 Dokdo Sun Cream$18.99 USD

100 Collagen Reedle Shot Stick Pouch$9.49 USD

100 PRO CICA Reedle Shot Stick Pouches$9.49 USD

1025 Dokdo Cleanser$11.99 USD

Rich hydration, moisture-barrier support and a smoother, more radiant look—here's what this cream brings to your routine.

Rich, replenishing hydration
Moisture-barrier support
Smoother-looking pores
Firmer-looking skin
A fresh-looking glow

Key Ingredients

Seven rose and lilac glass lozenges form a loose sequence across a blush pedestal against a muted plum backdrop.

PDRN

A DNA-fragment skin conditioner commonly used to help skin look smoother, plumper and more resilient.

Overlapping ivory wax-like layers on a warm blush background, representing ceramide barrier lipids.

Ceramides

Barrier-supporting lipids that help reduce moisture loss and ease visible dryness.

Clear hydrogel spheres and droplets on a pale lilac background.

Hyaluronic Acid

Helps hydrate and visibly plump the skin.

Squalane

Softens dry-feeling skin and adds slip to skin, body, hair and makeup.

Panthenol

Pro-vitamin B5 that helps skin hold moisture and feel softer and more comfortable.

Niacinamide

Helps visibly brighten uneven tone and support the skin barrier.

Pleated lavender paper fan with a coral-red edge on a pale blush surface.

Adenosine

A skin-conditioning ingredient commonly used to help skin look smoother and soften the appearance of fine lines.

Real Results

20.8%Improvement in visible pore count after four weeks¹
71%Improvement in skin hydration after one use¹
185.8%Improvement in skin radiance immediately after one use^{1, 2}
2.5%Improvement in pore elasticity after five days²

View all 5 real results

105.4%

Open black squeeze tube angled beside its translucent purple cap on a pale blue background.

Concerns & Benefits

Your Concerns

1
Dehydration
When your skin feels short on moisture and you want a rich, replenishing cream.
2
Damaged Skin Barrier
When supporting your skin's moisture barrier is a priority.

How To Use

1After cleansing and toning, apply an appropriate amount evenly over your face as the final step of your skincare routine.
2Smooth the cream over your skin, then gently tap until absorbed. Leave it on.
3Use in the morning and evening.

Frequently asked questions

How should I apply it?

Apply an appropriate amount evenly over your face at the final step of your skincare routine. Smooth it over your skin, then gently tap until absorbed.

Customer reviews

Frequently Bought Together

Buy these products together

This itemPDRN Derma Cream$22.99 USD

100 RETI-A Reedle Shot$9.49 USD

100 Reedle Shot Stick Pouch$8.09 USD

Total price: $40.57 USD

This itemPDRN Derma Cream$22.99 USD

100 RETI-A Reedle Shot$9.49 USD

100 Reedle Shot Stick Pouch$8.09 USD

Total price: $40.57 USD

VT COSMETICS

100 RETI-A Reedle Shot

A beginner-friendly evening serum for smoother-looking texture, refined-looking pores and radiant skin.

2 ml × 10 sachets$9.49 USD

VT COSMETICS

100 Reedle Shot Stick Pouch

A travel-size evening booster for smoother-feeling, more refined-looking skin.

2 mL × 10$8.09 USD

VT COSMETICS

100 VITA-LIGHT Reedle Shot

A jelly-like evening ampoule for brighter, more even-looking skin in single-use pouches.

2 ml × 10 pouches$9.49 USD

ROUND LAB

1025 Dokdo Eye Cream

Lightweight daily eye care for hydration, brightness and smoother-looking fine lines.

30 ml / 1.01 fl oz$22.99 USD

ROUND LAB

1025 Dokdo Sun Cream

SPF 50+ PA++++ protection in a lightweight, no-white-cast lotion.

50 ml$18.99 USD

VT COSMETICS

100 Collagen Reedle Shot Stick Pouch

Beginner-friendly texture care with moisture, firmness and a refreshing, non-sticky finish.

2 ml × 10 sachets$9.49 USD

VT COSMETICS

100 PRO CICA Reedle Shot Stick Pouches

Daily texture care with soothing hydration, one travel-friendly pouch at a time.

2 ml × 10 pouches$9.49 USD

ROUND LAB

1025 Dokdo Cleanser

Creamy, slightly acidic foam for a comfortable cleanse

150 ml$11.99 USD

Mediheal PDRN Derma Cream | Hydration & Glow | Sleepy Hello

Mediheal

PDRN Derma Cream

What it is: A rich leave-on face cream that moisturizes while supporting a smooth, radiant-looking finish and the appearance of pores.

Moisture-barrier support
Rich, replenishing hydration
Smoother-looking pores
Radiant-looking finish

Net weight: 50 ml

PDRN Derma Cream

50ml ·$22.99 USD

Moisture-barrier support

Rich, replenishing hydration

Smoother-looking pores

Radiant-looking finish

Main active: PDRN
Intensity: Supportive

PRODUCT DETAILS

Hello, replenishment. This leave-on face cream brings rich, replenishing moisture and a smooth, radiant-looking finish to skin that feels short on hydration.

Learn more

GOES WELL WITH

100 RETI-A Reedle Shot$9.49 USD

100 Reedle Shot Stick Pouch$8.09 USD

100 VITA-LIGHT Reedle Shot$9.49 USD

1025 Dokdo Eye Cream$22.99 USD

1025 Dokdo Sun Cream$18.99 USD

100 Collagen Reedle Shot Stick Pouch$9.49 USD

100 PRO CICA Reedle Shot Stick Pouches$9.49 USD

1025 Dokdo Cleanser$11.99 USD

Rich hydration, moisture-barrier support and a smoother, more radiant look—here's what this cream brings to your routine.

Rich, replenishing hydration
Moisture-barrier support
Smoother-looking pores
Firmer-looking skin
A fresh-looking glow

Key Ingredients